Comparative Genomics of Heat Shock Protein in Pathogenic Bacteria

Abstract

Genome comparison has recently become a common research topic in computer science. The development of computer-assisted mathematics (using products such as Mathematica or Matlab) has helped engineers, mathematicians, and computer scientists to start operating in this domain, and a public collection of case studies and demonstrations is growing, ranging from whole genome comparisons to gene expression analysis. This has increased the introduction of different ideas, including concepts from systems and control, information theory, strings analysis, and data mining. It is anticipated that computational approaches will become and remain a standard topic for research and teaching, while students fluent in both topics start being formed in the multiple courses created in the past few years. In the present investigation, four pathogenic microorganisms have been selected. They are (1) Salmonella typhimurium, (2) Bacillus subtilis, (3) Mycobacterium tuberculosis, and (4) Thermoplasma acidophilum. In the above organisms, heat shock protein genes (HSP genes) sequences have been retrieved from the Bioinformatics databases.

Keywords: HSP genes, FASTA, NCBI/Gen Bank Database, Clustal W, B-galactosidase