Design and Development of Sustained Release Tablets using Solid Dispersion of Beclomethasone Dipropionate

Abstract

Abstract

In present study an attempt was made to enhance the solubility of beclomethasonedipropionate by solid dispersion method followed by formulating sustained release matrix tablet of beclomethasonedipropionate to improve the patient compliance. Beclomethasonedipropionate has poor water solubility and short elimination half-life hence solid dispersion of beclomethasonedipropionate were prepared with β-cyclodextrin and PEG 6000 as carrier by using physical mixture, solvent evaporation and kneading method. The prepared solid dispersions were evaluated for percentage yield, drug content and in vitro dissolution studies. From the in vitro dissolution data optimized formulation of solid dispersion was subjected for preparation of sustained release tablets by direct compression method using matrix polymers like HPMC K15 and guar gum. The FTIR study revealed that there was no interaction between the drug and polymer. The formulated tablets were further evaluated for thickness, weight variation, hardness, friability, drug content and in vitro dissolution studies. The results of in vitro dissolution studies revealed the sustained release of the drug. The best fitting model was found to be zero order. The stability studies revealed that the tablet was stable over a longer period of time.

Keywords: Beclomethasonedipropionate, β-cyclodextrin, PEG 6000, HPMC K15, guar gum, solid dispersion, sustained release

Cite this Article

Narayanacharyulu R, Krishna Sathwik C, Mudit Dixit. Design and development of sustained release tablets using solid dispersion of beclomethasone dipropionate. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2015; 2(3): 30–41p.