Visit to Visit Fasting Plasma Glucose Variability and Associated Factors in Diabetic Patients

Abstract

Wide glycemic variability has been proposed as one of the factors associated with poor glycemic control and development of diabetes complications. The aim of this study was to evaluate the extent of visit to visit fasting plasma variability and associated factors in patients with diabetes. A retrospective cross-sectional study was conducted on 280 diabetic patients attending outpatient diabetic clinic of Ayder Referral hospital between December, 2015 and April, 2016. Relevant data were collected using face to face interview, laboratory investigation, and review of patients’ medical records. Month to month variability of fasting plasma glucose (FPG) was assessed using mean, standard deviation (SD) and coefficient of variations (CV). Chi-square, student t-test, binary and multivariate logistic regression analysis were used to assess any significant differences among independent variables and their associations with wide glycemic variability. Mean duration of diabetes since diagnosis was 5.8 years in Type 1 and 6.5 years in Type 2 diabetic patients. According to CV of FPG, 56.5% of Type 1 and 49.2% of Type 2 diabetic patients had marked glycemic variability (CV>25). Current and mean FPG were >130 mg/dL in 59.8% and 65.2% of Type 1 and 66.7% and 72% of Type 2 diabetic patients, respectively. In Type 2 diabetic patients’ low educational status, low BMI and high mean FPG showed statistical significant association with wide glycemic variability. The results indicate high rate visit to visit glycemic variability. Additional efforts and targeted interventions are needed to improve inconsistent glycemic control.

Keywords: glycemic variability, diabetes complication, glycemic control

Cite this Article

Ketema and Abraha. Visit to Visit Fasting Plasma Glucose Variability and Associated Factors in Diabetic Patients. Research and Reviews: Journal of Medical Science and Technology. 2016; 5(2): 14–24p.