Small Cell Neuroendocrine Carcinoma of Cervix: A Case Report and Review

Abstract

related death in the developing country. Various histologic subtypes seen in cancer cervix, squamous cell carcinoma (70%) is the most common one. Second common variety observed is adenocarcinoma which account for about 25% of cases. Other histologic subtypes are rare. Small cell neuroendocrine cervical carcinoma (SCNCC) is one of such uncommon variant that comprises 1–3% of cervical tumors. It shows very aggressive behaviour. They usually present with similar symptoms as other subtypes but also exhibit characteristic of neuroendocrine tumour of other sites (early dissemination). The five year survival for patients with early stage Neuroendocrine Carcinoma (NEC) of the cervix ranges from 19–42%. Because of rarity of the disease, etiology and predisposing risk factors for the disease are rarely understood. And, despite of multimodal treatment approach disease has very poor prognosis. We present a case report of 37-year-old female presenting with neuroendocrine tumour of cervix post hysterectomy and post radiation for squamous cell carcinoma of cervix. She was given chemotherapy and patient was disease free at 1 year follow up post treatment. Despite early diagnosis, neuroendocrine tumour of cervix has poor prognosis. There is need of further research and standard guidelines for the management of the disease.

Keywords: Neuroendocrine tumour, cervix, small cell cancer, prognosis, squamous cell carcinoma

Cite this Article

Rajnish Nagarkar, Sirshendu Roy, Tejashree Deshpande. Small Cell Neuroendocrine Carcinoma of Cervix: A Case Report and Review. Reseach & Reviews: Journal of Oncology & Hematology. 2016; 5(2): 15–18p.