Relation of Thyroid Profile in Gall Stone Disease Patients

Abstract

Abstract

Introduction: Gallstone disease is a very common gastro-intestinal disorder which is present world wide. They may form because of many different disorders and the basis for it is impaired metabolism of cholesterol, bilirubin and bile acid and is characterized by formation of stones in hepatic or common bile duct or gall bladder. There has been a discussion, regard to the relation of thyroid disorders and gallstone disease, there are several explanations for a possible relation between hypothyroidism and gallstone disease. Further, sphincter of Oddi expresses thyroid hormone receptors and thyroxine has a direct pro-relaxing effect on sphincter, recent studies have also demonstrated low bile flow in hypothyroid patients. Hence, the aim of our study is to study relation of thyroid profile in patients of gall stone disease. Methods: Data was collected by estimating thyroid profile in patients of gall stone disease who were admitted in department of general surgery, Dr SN Medical College, Jodhpur from January 2015 to December 2016. Statistical analysis was done on collected data and p value was determined. P value <0.05 indicates statistically significant association. Results: In our study conducted on 50 patients, only 3(6%) had hypothyroidism and all of them were females. Most common age group having hypothyroidism was 45–60 years RESULTS-In. None of the male was hypothyroid. This non-significance can be due to the fact that those patients who were already diagnosed as having thyroid disorders were not included in the study and even in those patients having hypothyroidism with gallstone disease; it could not be solely attributed to deranged thyroid profile because all patients had associated higher BMI and dyslipidaemia. Conclusion: There is no statistically significant correlation between deranged thyroid profile and gallstone disease.

Keywords: Gallstone disease, thyroid profile, hypothyroidism, BMI, dyslipidaemia

Cite this Article

Latika Sharma, Poojan Purohit, Rohit Dhawan et al. Relation of Thyroid Profile in Gall Stone Disease Patients. Research and Reviews: Journal of Surgery. 2017; 6(2): 8–12p.