Computer Simulations on Magnetic Particles Capturing in an Implant Assisted Channel for Targeted Drug Delivery

Abstract

In this paper, we studied the effect of magnetic field, inlet velocity and particle size on capture efficiency of magnetic particles transported in an implant assisted uniform channel through computational simulations. The dominant magnetic and drag forces are included in the simulations. The couple nonlinear Navier-Stokes equation for fluid flow and Newton’s second law equation for particle transport are solved using finite element based COMSOL multiphysics software. It is found that capture efficiency increases from 70–80% as we increase the external magnetic field strength from 2–3.5 Tesla. Further, the decrease in capture efficiency is observed from 80– 60% by increasing the inlet velocity from 20–50 mm/s. Enhancement in capture efficiency from 20–100% is observed by increasing the size of magnetic particles from 100 nm to 1.5 µm, respectively.

Keywords: Targeted drug delivery, magnetic nanoparticles, Ferromagnetic stent

Cite this Article

Prakash Chandra, Shashi Sharma, Anurag Gaur, Dharmendra Tripathi.
Computer Simulations on Magnetic Particles Capturing in an Implant Assisted Channel for Targeted Drug Delivery. Trends in Drug Delivery. 2015; 2(2): 1–7p.