Insilco Phylogenomic Analysis of Inhibin gene Family Members

Authors

  • Muhammad Waqas Khokhar Department of Biosciences, COMSATS Institute of Information Technology, Sahiwal, Pakistan
  • Sonia Kanwal Department of Biosciences, COMSATS Institute of Information Technology, Sahiwal, Pakistan

Keywords:

Inhibin, Phylogenomic analysis, segmental duplication

Abstract

The macro evolutionary events lead to anatomical complexity achieved by higher vertebrates. The extensive gene duplication results in widespread existence of gene families in modern vertebrates. TGF-β superfamily of cytokines contains majorly four mammalian inhibin-β subunits (βA, βB, βC, and βE). These are involved in gonadal functions (mammary gland development, cell proliferation, embryonic development). The overexpression leads to several cancers (metastatic prostate cancer, colorectal cancers, and cervical cancer). The phylogenomic analysis of INHB gene family was carried out to check the evolutionary history and functional significance. The colossal amount of diversified protein dataset for a wide variety of vertebrates, invertebrates was used to derive the mode of evolution, and conservation of functionally significant diverse gene family residing on the human chromosomes. Phylogeny advocates the expansion of multigene families, which occurred after the diversification of vertebrates from urochordates and prior to fish-tetrapod split. The major duplications occur within the time window of deuterostomes-protostomes and actinopterygii-sarcopterygii split. INHB exhibits a chromosomal topology of form (Hsa12) (Hsa7 Hsa2). Phylogenetic tree reflects chromosomal segmental duplications or small-scale duplications which occurred at different time points during chordate evolution. The study will provide better understanding of ancestral relationship and functional behavior of human multigene families for scientist belonging to diversified fields of biology especially comparative and evolutionary genomics biologist.

Keywords: Inhibin, phylogenomic analysis, segmental duplication

Cite this Article

Muhammad Waqas Khokhar, Sonia Kanwal. Insilco Phylogenomic Analysis of Inhibin gene Family Members. Research and Reviews: Journal of Computational Biology. 2016; 5(1):    25–32p.


 

Downloads

Published

2016-05-12

Issue

Vol. 5 No. 1 (2016)

Section

Research/Review Articles

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is notpublished already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  • I/We also agree to the authorship of the article in the following order:

Author’s name

 

1. ________________

2. ________________

3. ________________

_______________

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.