Formulation and Evaluation of Meloxicam Crystals Using Spherical Crystallization for Solubility Enhancement
Keywords:
Meloxicam, Solubility enhancement techniques, Box – Behnken, Optimization, Spherical Agglomerate tablets.Abstract
Abstract
The present study deals with spherical crystallization of Meloxicam crystals in order to improve the flow properties, compressibility and enhancement of dissolution characteristics of drug crystals. Spherical agglomerates of Meloxicam are prepared by different techniques. Selection of neutralization technique is based on the better percentage yield, drug content, and scanning electron microscopy (SEM) analysis. Optimization of Meloxicam spherical agglomerate was done. The micromeritic properties, solubility, in vitro drug release of spherical agglomerates were evaluated. Spherical agglomeration enhances the micromeritic and dissolution properties of Meloxicam. Optimized formulation of spherical agglomerate was chosen for the preparation of tablet. Response surface methodology using Box–Behnken was chosen for the optimization of spherical agglomerates. Spherical agglomerate tablet was prepared and evaluated and its dissolution characteristics were compared with conventional as well as marketed product. The tablet prepared from spherical agglomerate leads to a faster release of drug within 2 h when compared with marketed formulation. The drug release mechanism from the tablets was found to be non-Fickian kind of diffusion.
Keywords: Meloxicam, solubility enhancement techniques, Box–Behnken, optimization, spherical agglomerate tablets
Cite this Article
Arun Raj R, Nandkishore K. Formulation and Evaluation of Meloxicam Crystals Using Spherical Crystallization for Solubility Enhancement. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2016; 3(2): 15–35p.
Downloads
Published
Issue
Section
License
Copyright Transfer and Declaration Form (Please compile this form, sign and send by e-mail and post)
Journal Title:
Title of the Paper:
Corresponding Author’s Information: Name: Address:
E-mail:
Contact Number: I
t is herein agreed that: The copyright to the above-listed unpublished and original article is transferred to STM Journals. This copyright transfer covers the exclusive right to reproduce and distribute the contribution, including reprints, translations, photographic reproductions, microform, electronic form (offline, online), or any other reproductions of similar nature. I/We declare that above manuscript is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere. I/ We warrant(s) that his/her/their contribution is original, except for such excerpts from copyrighted works as may be included with the permission of the copyright holder and author thereof, that it contains no libelous statements, and does not infringe on any copyright, trademark, patent, statutory right, or propriety right of others. I/We will not publish his/her/their above said contribution anywhere else without the prior written permission of the publisher unless it has been changed substantially.I/We also agree to the authorship of the article in the following order:Author(s) Name Signature(s)
1. ________________
2. _______________
_3. ________________
4. ________________
The author(s) agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal (comments if any to the editor can be added below).
