Preparation and Characterization of Solid Dispersion of Tenoxicam

Authors

  • Mudit Dixit Head-Department of Pharmaceutics, NGSM Institute of Pharmaceutical sciences, Panner, Nitte University, Mangalore-575018, Karnataka, India
  • R Narayana Charyulu
  • Amit Patil
  • CS Shastry

Abstract

The aim of the present study was to prepare solid dispersions of a poorly water-soluble drug Tenoxicam in Polyvinylpyrrolidone (PVP), prepared by spray-drying techniques. The physicochemical properties of the solid dispersion and drug-polymer interactions were characterized by DSC, FT-IR, XRD and SEM. Tenoxicam was found amorphously dispersed in solid dispersion systems with the drug to polymer weight ratio of 1:3. Dissolution profile of the prepared solid dispersion was compared with commercial sample. The solubility of prepared solid dispersion exhibited increases in solubility and dissolution than the commercial Tenoxicam.

Keywords: Spray Drying, Solid Dispersion, Tenoxicam, Polyvinylpyrrolidone, Solubility, Dissolution

Cite this Article

Dixit Mudit, Narayana Charyulu R, Patil Amit, et al. Preparation and characterization of solid dispersion of Tenoxicam. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2015; 2(1): 23–29p.


 

Author Biography

  • Mudit Dixit, Head-Department of Pharmaceutics, NGSM Institute of Pharmaceutical sciences, Panner, Nitte University, Mangalore-575018, Karnataka, India
    Department of Pharmaceutics

Downloads

Published

2015-04-08

Issue

Vol. 2 No. 1 (2015)

Section

Research Articles

License

Copyright Transfer and Declaration Form (Please compile this form, sign and send by e-mail and post)

Journal Title:

Title of the Paper:

Corresponding Author’s Information: Name: Address:

E-mail:

Contact Number: I

t is herein agreed that: The copyright to the above-listed unpublished and original article is transferred to STM Journals. This copyright transfer covers the exclusive right to reproduce and distribute the contribution, including reprints, translations, photographic reproductions, microform, electronic form (offline, online), or any other reproductions of similar nature. I/We declare that above manuscript is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere. I/ We warrant(s) that his/her/their contribution is original, except for such excerpts from copyrighted works as may be included with the permission of the copyright holder and author thereof, that it contains no libelous statements, and does not infringe on any copyright, trademark, patent, statutory right, or propriety right of others. I/We will not publish his/her/their above said contribution anywhere else without the prior written permission of the publisher unless it has been changed substantially.I/We also agree to the authorship of the article in the following order:Author(s) Name Signature(s)

1. ________________

2. _______________

_3. ________________

4. ________________

The author(s) agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal (comments if any to the editor can be added below).