Correlation of Ki-67 Score with Nottingham Histological Grading in Carcinoma Breast: A Single Institution Experience

Authors

  • Garima Verma Department of Pathology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India
  • Vijay Verma Department of Pathology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India
  • Vibha Rani Pipal Department of Pathology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India
  • Dharmendra Kumar Pipal Department of Pathology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India

Keywords:

Nottingham grading, Tubule formation, Mitotic count, Nuclear pleomorphism

Abstract

Though it is reasonably well established that Ki-67 positivity is an independent predictor of ultimate prognosis and course of carcinoma breast and its recurrence, many lacunae exist. Ki -67 score correlation with histological grading will establish importance of nuclear antigen Ki-67 as prognostic factor in Indian population. This study was aimed to assess histological grading of breast carcinoma by Nottingham Grading System (Modified Scarff- Bloom- Richardson system) and to correlate the histological grading with Ki-67 score. The study was carried out in Department of pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi. A part retrospective and part prospective study was done on a total of 59 cases of carcinoma breast. 59 representative paraffin blocks of Modified Radical Mastectomy, lumpectomy or biopsies of carcinoma breast were included for the study. All stained slides were reviewed and the morphological diagnosis based on H & E staining was considered as a gold standard to be compared with Ki-67 staining. For Ki-67 immounohistochemistry, representative sections from paraffin blocks were taken on poly- L- lysine coated glass slides. T- test was applied to find significance of correlation between Ki-67 and tubule formation, nuclear pleomorphism and mitotic count. ANOVA test was used to find the significance of correlation between Ki-67 and histological Grade. Results showed statistically significant correlation between Ki-67 score and Nottingham Histological Grade.

Keywords: Nottingham grading, Tubule formation, Mitotic count, Nuclear pleomorphism

Cite this Article

Garima Verma, Vijay Verma, Vibha Rani Pipal et al. Correlation of Ki-67 Score with Nottingham Histological Grading in Carcinoma Breast: A Single Institution Experience. Research & Reviews: Journal of Oncology & Hematology. 2017; 6(1): 1–5p.


Author Biography

  • Vijay Verma, Department of Pathology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India
    Assistant Professor,Department of Surgery
    Dr. S.N. Medical College,Jodhpur

Downloads

Published

2017-03-04

Issue

Vol. 6 No. 1 (2017)

Section

Research Articles

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is notpublished already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  • I/We also agree to the authorship of the article in the following order:

Author’s name

 

1. ________________

2. ________________

3. ________________

_______________

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.