In silico 3D Structure Modeling and Analysis of Galactoside 2-alpha-L-fucosyltransferase 1

Abstract

A rare group of blood known as Bombay blood group was discovered in Mumbai formerly known as Bombay more than five decades ago, which lacks A, B, AB and O type. A theoretical model of human Galactoside 2-alpha-L-fucosyltransferase 1/FUT gene is predicted. The model was generated by application of homology modeling and structure prediction approaches. As the template homology to the query sequence is too low a multiple online modeling and prediction server is used. The output has a several challenge with poor homology and predicted results, finally a scratch server and HH-pred server output showed some promising results with 100% query coverage model generation and validated using ProSA and PROCHECK.

Keywords: In silico, homology modeling, Galactoside 2-alpha-L-fucosyltransferase, Fut 1