Insilco Phylogenomic Analysis of Inhibin gene Family Members

Abstract

The macro evolutionary events lead to anatomical complexity achieved by higher vertebrates. The extensive gene duplication results in widespread existence of gene families in modern vertebrates. TGF-β superfamily of cytokines contains majorly four mammalian inhibin-β subunits (βA, βB, βC, and βE). These are involved in gonadal functions (mammary gland development, cell proliferation, embryonic development). The overexpression leads to several cancers (metastatic prostate cancer, colorectal cancers, and cervical cancer). The phylogenomic analysis of INHB gene family was carried out to check the evolutionary history and functional significance. The colossal amount of diversified protein dataset for a wide variety of vertebrates, invertebrates was used to derive the mode of evolution, and conservation of functionally significant diverse gene family residing on the human chromosomes. Phylogeny advocates the expansion of multigene families, which occurred after the diversification of vertebrates from urochordates and prior to fish-tetrapod split. The major duplications occur within the time window of deuterostomes-protostomes and actinopterygii-sarcopterygii split. INHB exhibits a chromosomal topology of form (Hsa12) (Hsa7 Hsa2). Phylogenetic tree reflects chromosomal segmental duplications or small-scale duplications which occurred at different time points during chordate evolution. The study will provide better understanding of ancestral relationship and functional behavior of human multigene families for scientist belonging to diversified fields of biology especially comparative and evolutionary genomics biologist.

Keywords: Inhibin, phylogenomic analysis, segmental duplication

Cite this Article

Muhammad Waqas Khokhar, Sonia Kanwal. Insilco Phylogenomic Analysis of Inhibin gene Family Members. Research and Reviews: Journal of Computational Biology. 2016; 5(1):    25–32p.