Insight into Phylogenomic Analysis of HNRNP’s Gene Family

Abstract

The macro evolutionary events during the vertebrate lineage plays a key role in shaping vertebrate genome and in creating anatomical complexity achieved by higher vertebrates. The extensive gene duplications results in widespread existence of gene families in modern vertebrates. HNRNPs are nuclear RNA binding proteins and are involved in transportation, metabolism, regulation, and stability. The abnormal expression of HNRNPs leads to lung, pancreatic and gastric carcinomas. The HnRNPs gene family comprises of four paralogues (hnRNPA0, hnRNPA1, hnRNPA2/B1, hnRNPA3).The colossal amount of diversified protein dataset for a wide variety of vertebrates, invertebrates was used to derive mode of evolution and conservation of functionally significant diverse HnRNPs gene family residing on vertebrate genome. Phylogeny advocates the expansion of multigene families which occurred after diversification of vertebrates from urochordates and prior to fish-tetrapod split. The major duplications occur within the time window of deuterostomes-protostomes and actinopterygii-sarcopterygii split. Phylogenetic tree reflects chromosomal segmental duplications or small scale duplications which occurred at different time points during chordate evolution. The study will provide better understanding of ancestral relationship and functional behavior of human multigene families for scientist belongs to diversified fields of biology especially comparative and evolutionary genomics biologist.

Keywords: EF-hand-like domains, transcriptional repressors, lineage specific duplications

Cite this Article

Khokhar, Arshad, Amin. Insight into Phylogenomic Analysis of hnRNP’s Gene Family. Research & Reviews: Journal of Computational Biology. 2016; 6(2): 27–32p.