QSAR Studies on Schiff Bases of Pyrrole-2-Carboxaldehyde for Antimicrobial Activity

Abstract

Abstract

Pyrrole and Schiff bases are therapeutically significant organic moieties. QSAR (Quantitative structure-activity relationship) studies of thirteen pyrrole-2-carboxyaldehyde Schiff bases have been described for antimicrobial activity against S. epidermidis, E. coli and S. aureus. Described 2D QSAR models are statistically significant models with good fitting ability and robustness. The Q² value is more than 0.5 for all discussed models which confirms the internal predictive power of the derived QSAR equations. Molecular weight, autocorrelation descriptors and burden modified eigenvalues descriptors were important in explanation of antimicrobial activity trends.

Keywords: Schiff bases, antimicrobial, QSAR, descriptors

Cite this Article

Ashwani Kumar, Pardeep Kumar, Parvin Kumar. Qsar Studies on Schiff Bases of Pyrrole-2-Carboxaldehyde for Antimicrobial Activity. Research & Reviews: A Journal of Drug Design & Discovery. 2016; 3(3): 1–8p.