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Formulation and In vitro Evaluation of Oral Fast Dissolving Tablets of A Novel Antidepressant Drug by Using Camphor As A Subliming Agent

S D Sandeep, C R Narayana, Nayak P, Dixit M



The purpose of the present investigation is to formulate fast dissolving tablets of Venlafaxine HCl, a novel antidepressant by direct compression method using camphor as subliming agent in the three different concentrations of 2%, 5% and 10%. Croscarmellose, tulsion-414 and sodium starch glycolate were used as superdisintegrants in two different concentrations of 5% and 10%. The drug-excipients compatability was ruled out through FTIR studies. A total of six formulations were prepared with different concentrations of camphor and superdisintegrants. The prepared tablets were evaluated for thickness, hardness, friability, weight variation, drug content and in vitro dispersion time, wetting time and in vitro drug release. All the evaluation parameters were found to be within the limits of IP specifications. The disintegration time was found to be linearly decreases with the increase in the amount of superdisintegrant and camphor whereas the dissolution rate linearly increases. Among all the six formulations the tablets formulated with sodium starch glycolate with camphor were shown highest percentage of drug release within 10 minutes. It was concluded that oral fast dissolving tablets of Venlafaxine HCl can be successfully formulated by direct compression with camphor as subliming agent.

Keywords: Venlafaxine HCl, camphor, superdisintegrants, sublimation

Cite this Article

Sandeep SD, Narayana CR, Nayak P et al. Formulation and In vitro evaluation of oral fast dissolving tablets of a novel antidepressant drug by using camphor as a subliming agent. Research & Reviews: A Journal of Drug Design and Discovery. 2015; 2(3): 12–18p.


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