Formulation Development and Evaluation of Opthalmic Ocusert Containing Timolol Maleate

Abstract

Abstract

The aim of formulating timololmaleate occusert was to prolong the drug residence time after ocular administration to achieve the controlled release of drug. Timolol maleate is an antiviral agent and it is used in the treatment of viral infections like herpes simplex infections. Ocular inserts were prepared by solvent casting method. Drug reservoir and rate controlling membrane were prepared using different hydrophilic and hydrophobic polymers respectively with polyethylene glycol 400 as the plasticizer. The ocuserts were evaluated for their physical and chemical and in vitro release characteristics. The developed formulation was stable sterile and non-irritant. The final formulation F2 was subjected to UV irritation for sterilization. In the present work it was concluded that the F2 formulation shows 99.80% controlled release upto 8 h when compared to other formulations.

Keywords: Timolol maleate, ocusert, hydroxy propyl cellulose

Cite this Article

Shanmugam S, VetrichelvanT. Formulation Development and Evaluation of Opthalmic Ocusert Containing Timolol Maleate.Research & Reviews: A Journal of Drug Formulation, Development and Production. 2017; 4(1): 8–12p.