Formulation and Development of Gastroretentive Hydrogels of Glipizide

Abstract

Abstract

The aim of the present study was to develop a pH sensitive gastroretentive drug delivery system for an antidiabetic drug glipizide, based on gas formation technique using 32-factorial design, in order to prolong the gastric residence time and increase the overall bioavailability of the dosage form, since the absorption is erratic in diabetic patients. The system consists of the drug, glycol chitosan (5% w/w) and aqueous PVA solution (10% w/w) which were mixed together and pH was adjusted to 4.5–5.0. Then the crosslinking agent (10% aqueous glyoxal) was added, followed by sodium bicarbonate which acts as foaming agent. In acidic environment, superporous hydrogels showed higher swelling ratio because of the cationization of amine groups. The presence of PVA and increased levels of crosslinker significantly improved the mechanical strength of the superporous hydrogels. The drug release studies showed that sustained release of drug could be achieved with high crosslink density and higher amount of PVA.

Keywords: Hydrogels, pH sensitive, gastroretentive, glipizide, factorial design

Cite this Article

Vasanth Samaga, Puranik SB. Formulation and Development of Gastroretentive Hydrogels of Glipizide. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2017; 4(1): 1–7p.