Characterization of Tabletting Properties of Mango Gum

Abstract

The aim of the study is to elucidate the physical, thermal, sorption, and functional properties of a mango gum obtained from the stem of Mangifera indica were characterized viz. elemental analysis, Fourier transmittance infrared, particle size analysis, thermogravimetric analysis, differential scanning colorimetry, scanning electron microscopy, and X-ray powder diffraction. Mango gum had a glass transition temperature (T_g) and melting peak of 90 and 318.795°C, respectively. This material showed a 14.59% loss in weight at 200°C. The sample had peaks at approximately 21°, 29°, and 39° 2θ degrees of 2-theta (θ) in the X-ray powder diffraction pattern. Elemental analysis showed that mango gum contains 35.62, 6.12, 56.57, and 1.67% of carbon, hydrogen, oxygen, and nitrogen, respectively. The results obtained in this study establish the fundamental characteristics of mango gum. The in vitro drug release was found to be 95.07% at 30 min ketoprofen tablets with 2.5% w/w binder concentration showed optimum results than standard binder, thus conclusion was drawn that mango gum was found to be useful for the preparation of uncoated tablet dosage form.

Keywords: Mangifera indica, mango gum, tablet binder, excipients, ketoprofen