A Review on Novel Emulsification Technique: A Nanoemulsion

Abstract

Abstract

Kinetically stable and isotropic system of submicron size range is the nanoemulsion. In this system two immiscible liquids are mixed together to form a single-phase system with the identical concentration and ratio of surfactant and cosurfactant. Nanoemulsion droplet sizes fall typically in the range of 20- 200 nm.  Some literature suggest this range below 100 nm with shows narrow size distribution. In this review, major focus is given on the factor affecting formation of nanoemulsion, different approaches for their preparation and aspect for characterization. There are various application of the nanoemulsions, several techniques are to be used for preparation of nanoemulsions like phase titration with ultrasonication, microfluidization, high pressure homogenization, and solvent evaporation method. and parameter that are to be used for its characterization like Thermodynamic stability, globule size, surface charge refractive index, viscosity, TEM (transmission electron microscopy), scattering technique, drug release study etc.. This system is also applicable for target delivery and approaches are from oral, transdermal, ocular and parenteral too. Nanoemulsions have the potential in pharmaceutical industries because of the transparency (approximately 100%) and used as a tool for improving bioavailability of the Biopharmaceutical class II and IV Drugs. Nanoscale architecture of this system aid some physical properties such as optical transparency and unusual elastic behaviour. Nanoemulsions have widespread applications in different fields such as pharmaceutics, food technology, and cosmetics.

Keywords: Nanoemulsion, Submicron size droplet, Self-emulsifying agent, Drug delivery system

Cite this Article

Vivek P. Chavda, Dhaval Shah. A review on Novel Emulsification Technique: A Nanoemulsion. Trends in Drug Delivery. 2016; 3(2): 25–34p.