Comparative Study of Natural and Synthetic Humectants Present in Calamine Lotion

S. Valarmathi, M. Senthil Kumar, S. Shanmugam, C. Seventhi, C. Jensi, T. Vishali, S. Mythily, S. Santhiya



Lotions are defined as monophasic liquid dosage form. Lotions are designed to be applied to the skin without friction [1]. Lotions may contain humectants, so that moisture is retained on the skin after the lotions are applied [2]. Humectants are the substance that prevents the skin from drying. In this research work, the natural and synthetic humectants are used in order to prevent the water loss and to keep the skin moistening [3]. The natural humectants used are honey and synthetic humectants used are urea. The calamine lotions are formulated with the formulation code of F1, F2 and F3. The F1 formulation contains honey as natural humectants, F2 formulation contains urea as a synthetic humectants and the F3 formulation contains both synthetic and natural humectants. The thickening agent used is methyl cellulose which produces colloidal formulation. Methyl cellulose can be used for both, topical and oral preparations. The viscosity improving agents are used in the formulation, so that the contact time with skin is increased. The prepared formulation was evaluated for stability, pH, viscosity, visual appearance etc. The F3 formulation containing both natural and synthetic humectants was found to be effective as it has good viscosity, similar pH to skin.

Keywords: Humectants, calamine, antiseptic, honey, urea, methyl cellulose

Cite this Article

Valarmathi S, Senthil Kumar M, Shanmugam S et al. Comparative Study of Natural and Synthetic Humectants Present in Calamine Lotion. Trends in Drug Delivery. 2017; 4(1): 18–21p.


Full Text:

 Subscribers Only


  • There are currently no refbacks.