Formulation and Evaluation of Transdermal Drug Delivery of Piroxicam

Abstract

The aim of the present study was to formulate transdermal films loaded with Piroxicam (PX). Transdermal films were yare by utilizing sodium alginate (SA) and xanthan gum (XG) as biopolymers by varying the coalescence ratios viz., 10:0, 8:2, 6:4, 4:6 and 2:8 (w/w %) through solution casting method. The drug loaded membranes were evaluated for thickness, tensile comportments, and content uniformity. In-vitro diffusion was resolute by Franz diffusion cell. Piroxicam was found to be compatible and stable with the prepared formulation as attested by Fourier transform infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC), studies. Invitro release studies revels efficacy after 24 h. The study results suggest that biopolymer predicated Transdermal films are potential conveyances for amended transdermal distribution of PX for efficacious therapy.

Keywords: Piroxicam, Sodium alginate, Xanthan gum, Transdermal release, Skin permeation