Liquid Crystals as Novel Drug Carrier: A Review

Abstract

Liquid crystal is a thermodynamic stable phase characterized by anisotropic properties, generally lying in the temperature range between the solid and isotropic liquid phase, hence are termed mesophase. Based on the way that liquid crystals are obtained, they can be classified into two types—thermotropic liquid crystals and lyotropic liquid crystals. The thermotropic liquid crystal is generated by variation of temperature in the liquid state, while the lyotropic liquid crystal is formed by dissolving the compound in certain solvents. These primary phases are further sub-classified which will be discussed later. Recently, liquid crystals are studied as novel drug carrier systems. The reason for this interest is due to the extensive similarity of these colloidal systems to those in living organism and their superior advantageous properties over traditional dermal, parenteral and oral dosage forms. As research into this field continues and as new applications are developed, liquid crystals will play a vital role in modern technology. The purpose of this review is to focus on types, properties and applications of liquid crystals. Liquid crystals-based delivery systems such as creams, ointments, gels, liposomes, colloidal dispersions and transdermal patches have been used in pharmaceuticals and cosmetics. Liquid crystals have many applications in the fields of science, engineering and device technology. Liquid crystal-based systems can provide specific advantages of thermodynamic stability, high solubilisation levels, improved bioavailability, protection against oxidation and controlled release properties to the pharmaceuticals.

Keywords: Liquid Crystals, Mesophases, Thermotropic, Lyotropic, Drug Carrier

Cite this Article:

Deshprabhu N, Charyulu RN, Dixit M. Liquid Crystals as Novel Drug Carrier: A Review. Trends in Drug Delivery. 2015; 2(1): 1-9p.