In silico 3D Structure Modeling and Analysis of Galactoside 2-alpha-L-fucosyltransferase 1

Authors

  • Jasnaik Danish I Department of Biotechnology and Bioinformatics, D Y Patil University, Plot 50, Sector 15 CBD Belapur, Navi Mumbai, 400614, Maharashtra, India
  • L Hariharan Department of Biotechnology and Bioinformatics, D Y Patil University, Plot 50, Sector 15 CBD Belapur, Navi Mumbai, 400614, Maharashtra, India
  • Gupta Pramodkumar P Department of Biotechnology and Bioinformatics, D Y Patil University, Plot 50, Sector 15 CBD Belapur, Navi Mumbai, 400614, Maharashtra, India

Abstract

A rare group of blood known as Bombay blood group was discovered in Mumbai formerly known as Bombay more than five decades ago, which lacks A, B, AB and O type. A theoretical model of human Galactoside 2-alpha-L-fucosyltransferase 1/FUT gene is predicted. The model was generated by application of homology modeling and structure prediction approaches. As the template homology to the query sequence is too low a multiple online modeling and prediction server is used. The output has a several challenge with poor homology and predicted results, finally a scratch server and HH-pred server output showed some promising results with 100% query coverage model generation and validated using ProSA and PROCHECK.

Keywords: In silico, homology modeling, Galactoside 2-alpha-L-fucosyltransferase, Fut 1

 

Author Biographies

  • Jasnaik Danish I, Department of Biotechnology and Bioinformatics, D Y Patil University, Plot 50, Sector 15 CBD Belapur, Navi Mumbai, 400614, Maharashtra, India
    Bioinformatics
  • L Hariharan, Department of Biotechnology and Bioinformatics, D Y Patil University, Plot 50, Sector 15 CBD Belapur, Navi Mumbai, 400614, Maharashtra, India
    Bioinformatics
  • Gupta Pramodkumar P, Department of Biotechnology and Bioinformatics, D Y Patil University, Plot 50, Sector 15 CBD Belapur, Navi Mumbai, 400614, Maharashtra, India
    Bioinformatics, Assistant Professor

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Published

2014-11-03

Issue

Vol. 1 No. 3 (2014)

Section

Research Articles

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