Development and Characterization of Mucoadhesive Microspheres Containing a Model Antidiabetic Drug

Authors

  • R. Narayana Charyulu Head-Department of Pharmaceutics, NGSM Institute of Pharmaceutical sciences, Panner, Nitte University, Mangalore-575018, Karnataka, India
  • Sompalli Prashanthi
  • Mudit Dixit
  • Nisha G. Shetty

Abstract

The present work was envisaged to reduce the dosing frequency and improve patient compliance by designing and evaluating sustained release mucoadhesive (SRM) microspheres of metformin hydrochloride (MH) for an effective control of diabetes type-2. Microspheres were prepared by emulsification solvent evaporation method using sodium alginate, carbopol 934P (CP), and sodium carboxy methyl cellulose (SCMC) as a mucoadhesive polymers. The microspheres exhibits good mucoadhesive properties and showed high drug entrapment efficiency. MH release from these microspheres was slow and extended and dependent on the type of polymer used. The data obtained thus suggest that mucoadhesive microspheres can be successfully designed for sustained delivery of metformin hydrochloride and to improve patient compliance.

Keywords: Microspheres, diabetes mellitus type-2, mucoadhesion, controlled drug release, sodium alginate, carbopol, sodium carboxy methyl cellulose

Cite this Article

Charyulu R Narayana, Prashanthi Sompalli, Dixit Mudit, et al. Development and characterization of mucoadhesive microspheres containing a model antidiabetic drug. Research & Reviews: A Journal of Drug Design & Discovery. 2015; 2(2): 12–19p.

 

Author Biography

  • R. Narayana Charyulu, Head-Department of Pharmaceutics, NGSM Institute of Pharmaceutical sciences, Panner, Nitte University, Mangalore-575018, Karnataka, India
    Department of Pharmaceutics

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Published

2015-07-22

Issue

Vol. 2 No. 2 (2015)

Section

Research Articles

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