Spectrofluorimetric Method for the Estimation of Avanafil in Bulk and their Tablet Dosage Form

Authors

  • Pratik M. Tailor
  • Vrutika V. Patel
  • Ashish D. Mishra
  • Shailesh A. Shah
  • Dinesh R. Shah

Abstract

Abstract

A simple and sensitive spectrofluorimetric method has been developed for estimation of Avanafil in bulk and in their tablet dosage form. Avanafil in methanol produces fluorescence at 367 nm (λem) with excitation at 314 nm (λex). Linearity range was found to be 200–1000 ng/ml with correlation co-efficient 0.999. The limit of detection (LOD) and limit of quantitation (LOQ) for the developed method were found to be 7.32 and 22.18 ng/ml, respectively. The developed method was found to be specific, sensitive, accurate and precise. It was successfully used for estimation of Avanafil in its tablet dosage form. The content of Avanafil in two marketed formulations was found to be 96.91 and 97.95% of label claim.

Keywords: Avanafil, spectrofluorimetric method, excitation, emission

Cite this Article

Pratik M. Tailor, Vrutika V. Patel, Ashish D. Mishra et al. Spectrofluorimetric Method for the Estimation of Avanafil in Bulk and their Tablet Dosage Form. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2016; 3(3): 17–21p.


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Published

2017-01-17

Issue

Vol. 3 No. 3 (2016)

Section

Research Articles

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