Design and Development of Sustained Release Tablets using Solid Dispersion of Beclomethasone Dipropionate
Abstract
Abstract
In present study an attempt was made to enhance the solubility of beclomethasonedipropionate by solid dispersion method followed by formulating sustained release matrix tablet of beclomethasonedipropionate to improve the patient compliance. Beclomethasonedipropionate has poor water solubility and short elimination half-life hence solid dispersion of beclomethasonedipropionate were prepared with β-cyclodextrin and PEG 6000 as carrier by using physical mixture, solvent evaporation and kneading method. The prepared solid dispersions were evaluated for percentage yield, drug content and in vitro dissolution studies. From the in vitro dissolution data optimized formulation of solid dispersion was subjected for preparation of sustained release tablets by direct compression method using matrix polymers like HPMC K15 and guar gum. The FTIR study revealed that there was no interaction between the drug and polymer. The formulated tablets were further evaluated for thickness, weight variation, hardness, friability, drug content and in vitro dissolution studies. The results of in vitro dissolution studies revealed the sustained release of the drug. The best fitting model was found to be zero order. The stability studies revealed that the tablet was stable over a longer period of time.
Keywords: Beclomethasonedipropionate, β-cyclodextrin, PEG 6000, HPMC K15, guar gum, solid dispersion, sustained release
Cite this Article
Narayanacharyulu R, Krishna Sathwik C, Mudit Dixit. Design and development of sustained release tablets using solid dispersion of beclomethasone dipropionate. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2015; 2(3): 30–41p.
Downloads
Published
Issue
Section
License
Copyright Transfer and Declaration Form (Please compile this form, sign and send by e-mail and post)
Journal Title:
Title of the Paper:
Corresponding Author’s Information: Name: Address:
E-mail:
Contact Number: I
t is herein agreed that: The copyright to the above-listed unpublished and original article is transferred to STM Journals. This copyright transfer covers the exclusive right to reproduce and distribute the contribution, including reprints, translations, photographic reproductions, microform, electronic form (offline, online), or any other reproductions of similar nature. I/We declare that above manuscript is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere. I/ We warrant(s) that his/her/their contribution is original, except for such excerpts from copyrighted works as may be included with the permission of the copyright holder and author thereof, that it contains no libelous statements, and does not infringe on any copyright, trademark, patent, statutory right, or propriety right of others. I/We will not publish his/her/their above said contribution anywhere else without the prior written permission of the publisher unless it has been changed substantially.I/We also agree to the authorship of the article in the following order:Author(s) Name Signature(s)
1. ________________
2. _______________
_3. ________________
4. ________________
The author(s) agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal (comments if any to the editor can be added below).
