Gene Therapy: A Newfangled Technology for Genetic Modification

Authors

  • Pothana Boyina Guru Vishnu Ph.D Scholar, INDIAN VETERINARY RESEARCH INSTITUTE, IZATNAGAR-243122, BARIELLY, U.P. INDIA
  • CSV Satish Kumar Ph.D Scholar, Department of Pharmacology & Toxicology, College of Veterinary Science, Rajendranagar-500 030, Sri Venkateswara Veterinary University, Hyderabad, India
  • Jowel Debnath Dr. Jowel Debnath, Assistant Professor, Department of Animal Genetics & Breeding C.V.Sc & A.H, R.K.Nagar, Govt. of Tripura, India
  • Raju Jakkula M.V.Sc Scholar, Division of Animal Nutrition, Indian Veterinary Research Institute, Izatnagar-243122, Barielly, U.P. India
  • P Ravi Kumar Professor, Department of Pharmacology & Toxicology, NTR College of Veterinary Science, Sri Venkateswara Veterinary University, Gannavaram - 521 102, India

Keywords:

Gene therapy, viral vectors, non-viral vectors, gene delivery systems, ethical issues

Abstract

Gene therapy provides modern medicine with new perspectives that were unthinkable two decades ago and it has been proposed as a future strategy to prevent aging. Gene therapy is “the use of genes as medicine” involving the transfer of a therapeutic or working copy of a gene into specific cells of an individual in order to repair a faulty gene copy. Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by use of recombinant viruses (sometimes called biological nanoparticles or viral vectors) or those that use naked DNA or DNA complexes (non-viral methods). Although gene therapy as a treatment for disease holds great promise, progress in developing effective clinical protocols has been slow. The problem lies in the development of safe and efficient gene-delivery systems. This review summarizes various methods, vectors and gene delivery techniques of gene therapy including current status and recent developments in gene therapy.

 

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Published

2013-01-10

Issue

Vol. 1 No. 3 (2012)

Section

Research/Review Articles

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