Inhibition of MDA-MB-231 Breast Cancer Cell Proliferation by Simple Diphenyl Chalcone and Its Chlorinated Derivative

Authors

  • Vitus A. Apalangya Department of Chemistry, Tuskegee University, Tuskegee, AL-36088
  • Thomas Bakupog Department of Chemistry, Tuskegee University, Tuskegee, AL-36088
  • Charmaine Tutson Department of Chemistry, Tuskegee University, Tuskegee, AL-36088
  • Sebastian Sefadzi Department of Chemistry, Tuskegee University, Tuskegee, AL-36088
  • Bernadette Early Department of Chemistry, Tuskegee University, Tuskegee, AL-36088
  • Roberta M. Troy Department of Biology, Tuskegee University, Tuskegee, AL-36088
  • Michael L. Curry Department of Chemistry, Tuskegee University, Tuskegee, AL-36088
  • Pamela M. L. Robinson Department of Chemistry, Georgia Perimeter College, Dunwoody, GA
  • Nichole L. Powell Department of Chemistry, Oxford College-Emory University, Oxford, Georgia-30054
  • Albert Eugene Russell Tuskegee University

Keywords:

Chalcone, anti-proliferation, synthesis, cancer

Abstract

The pharmacological activities of chalcones and their derivatives are well documented. Chalcones are an important class of natural products that occur in edible plants such as spices, tea, fruits and other vegetables. In vitro studies have shown that chalcones inhibit proliferation of breast cancer cells by inducing apoptosis and blocking cell cycle progression. Substituent effects, namely, adding electron-withdrawing substituents to the chalcone structural motif, and the extents to which those changes alter the anti-proliferative ability of chalcones have not been thoroughly investigated. Herein, we examine the introduction of chlorine to the aromatic system of the chalcone and how these electron-withdrawing substituents affect chalcone’s anti-proliferative ability.

Author Biography

  • Albert Eugene Russell, Tuskegee University
    Department of Chemistry Associate Professor

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Published

2012-09-11

Issue

Vol. 1 No. 2 (2012)

Section

Research Articles

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