Stomach Mimicry of A-Forte for Pharmacokinetic Insight
Abstract
Drug absorption from solid dosage forms after oral administration depends on the release of the drug substance from the drug product, the dissolution or solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. In vitro dissolution may be relevant to the prediction of in vivo performance. To evaluate the in vitro dissolution of A-forte, a siddha proprietary medicine and the influencing factors, a study of stomach mimicry for A-forte was undertaken. In the present study, the release of A-forte in different pH conditions by slow release and faster release pattern was studied. The release of actives was measured spectrophotometry. The possible variations caused because of A-forte to gastric media and influence of gastric media on A-forte was studied. Further the characteristics of various constituents of A-forte capsule released under different conditions were studied by Thin Layer Chromatography (TLC). The rate of dissolution of A-forte capsules was high in the low pH of 2 compared to high pH (4, 6.8). However, the pH of medium was decreased by excipient Phyllanthus emblica. pH altering property of Phyllanthus emblica may create an acidic micro-environment which may possibly cause gastric irritation. The herbal actives are however, not influenced by the pH and the rate of dissolution is unaffected by pH variation of medium as revealed by our subsequent TLC studies. The findings of the study are presented in the research paper.
Keywords: Pharmacokinetic, Stomach, A-forte, Psoriasis, TLC, Dissolution
Cite this Article
Amruthavalli GV, Gayathri Rajagopal, Stomach Mimicry of A-Forte for Pharmacokinetic Insight, Research and Reviews: A Journal of Unani, Siddha and Homeopathy (RRJoUSH) 2015; 2(2): 8–12p.
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