Computer Simulations on Magnetic Particles Capturing in an Implant Assisted Channel for Targeted Drug Delivery
Abstract
In this paper, we studied the effect of magnetic field, inlet velocity and particle size on capture efficiency of magnetic particles transported in an implant assisted uniform channel through computational simulations. The dominant magnetic and drag forces are included in the simulations. The couple nonlinear Navier-Stokes equation for fluid flow and Newton’s second law equation for particle transport are solved using finite element based COMSOL multiphysics software. It is found that capture efficiency increases from 70–80% as we increase the external magnetic field strength from 2–3.5 Tesla. Further, the decrease in capture efficiency is observed from 80– 60% by increasing the inlet velocity from 20–50 mm/s. Enhancement in capture efficiency from 20–100% is observed by increasing the size of magnetic particles from 100 nm to 1.5 µm, respectively.
Keywords: Targeted drug delivery, magnetic nanoparticles, Ferromagnetic stent
Cite this Article
Prakash Chandra, Shashi Sharma, Anurag Gaur, Dharmendra Tripathi.
Computer Simulations on Magnetic Particles Capturing in an Implant Assisted Channel for Targeted Drug Delivery. Trends in Drug Delivery. 2015; 2(2): 1–7p.
Downloads
Published
Issue
Section
License
Copyright Transfer and Declaration Form (Please compile this form, sign and send by e-mail and post)
Journal Title:
Title of the Paper:
Corresponding Author’s Information: Name: Address:
E-mail:
Contact Number: I
t is herein agreed that: The copyright to the above-listed unpublished and original article is transferred to STM Journals. This copyright transfer covers the exclusive right to reproduce and distribute the contribution, including reprints, translations, photographic reproductions, microform, electronic form (offline, online), or any other reproductions of similar nature. I/We declare that above manuscript is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere. I/ We warrant(s) that his/her/their contribution is original, except for such excerpts from copyrighted works as may be included with the permission of the copyright holder and author thereof, that it contains no libelous statements, and does not infringe on any copyright, trademark, patent, statutory right, or propriety right of others. I/We will not publish his/her/their above said contribution anywhere else without the prior written permission of the publisher unless it has been changed substantially.I/We also agree to the authorship of the article in the following order:Author(s) Name Signature(s)1. ________________2. ________________3. ________________4. ________________The author(s) agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal (comments if any to the editor can be added below).
